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Several in vivo studies have reported the toxicity of HTPs to the respiratory and circulatory systems since their introduction into the market in Japan in the early 2010s, but limited knowledge exists regarding toxicity to the central nervous system (CNS), particularly after long-term exposure to HTPs 5,6,7,8,9

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However, there are other ways that can cause mouth sores to develop including if you are experiencing a significant amount of stress, as well as depending on the medications you may currently be taking, amongst others

In the study of Groppetti et al

(2014) 349:g5501